Join us on Tuesday 29th January at 5:45pm for two presentations.
Lauren Wedekind will give a talk about Genome-wide association studies (GWAS) of traits related to type 2 diabetes: Inflammation and birth weight and Matt Courtis on Jet Engine Cooling: A look into cooling methods for the future of aerospace.
Genome-wide association studies (GWAS) of traits related to type 2 diabetes: Inflammation and birth weight
How do we study the genetic contribution to complex disease risk? First, this presentation will discuss basic definitions in genetic epidemiology, and contextualise present studies with details on previous genome-wide association studies (GWAS) and representation of populations of different ethnic backgrounds. Next, it will review the methods and results for GWAS of traits that are associated with type 2 diabetes: inflammatory factors (cytokines) and birth weight. Finally, it will discuss future directions for these studies, and how previous studies have utilized genetic associations to develop therapies for treating diabetes.
Lauren Wedekind is a DPhil student in Biomedical Sciences and the NIH-Oxford programme, working between Oxford and Phoenix. Lauren’s research combines her interests in health equity, cardiometabolic diseases, genetic epidemiology, and science communication. She enjoys running with Linacre Running Club.
Jet Engine Cooling: A look into cooling methods for the future of aerospace
Modern jet engines require high pressure ratios and turbine inlet temperatures to achieve increased power and higher thermal efficiency. Increased engine eﬃciency will reduce fuel costs and in turn has the capability to reduce CO2 emissions by over 180,000 kg per engine per year. Additionally application to hypersonic vehicles provides potential for reduced flight costs and performance. Typical temperatures into the turbine have increased up to 2100K (1827°C), which is well beyond the melting temperatures of metals used for the turbine blades. Consequently, cooling techniques have been introduced for suitable performance and engine reliability. Traditionally the use of internal cooling in conjunction with film cooling, have enabled inlet temperatures of up to 1700K, but more advanced cooling methods are required for additional thermal loads.
A method of increased interest is transpiration cooling, characterised by small film-cooling hole sizes, with a high coverage density, to achieve a suitable cooling performance for small coolant mass flow requirements. While work as early as the 1950s by NASA researched the impact of transpiration cooling, only recently has the development of manufacturing techniques enabled the possibility for such advanced cooling schemes to be implemented.
Born in Barbados and growing up in the Caribbean, aerospace didn't seem like a likely field to pursue. However, as a swimmer and sailor, fluid mechanics naturally sparked an interest. Matt Courtis is now a DPhil student at the University of Oxford researching Gas Turbine Aerodynamics. Matt graduated from the University of Oxford (MEng) in 2017 and the University of Cambridge (MRes) in 2018.